Hepatocellular carcinoma (HCC) is the most common primary cancer of the liver. Hepatectomy and liver transplantation (LT) are\nregarded as the radical treatment, but great majority of patients are already in advanced stage on the first diagnosis and lose the\nsurgery opportunity. Multifarious image-guided interventional therapies, termed as locoregional ablations, are recommended by\nvarious HCC guidelines for the clinical practice. Transarterial chemoembolization (TACE) is firstly recommended for\nintermediate-stage (Barcelona Clinic Liver Cancer (BCLC) B class) HCC but has lower necrosis rates. Radiofrequency ablation\n(RFA) is effective in treating HCCs smaller than 3 cm in size. Microwave ablation (MWA) can ablate larger tumor within a\nshorter time. Combination of TACE with RFA or MWA is effective and promising in treating larger HCC lesions but needs\nmore clinical data to confirm its long-term outcome. The combination of TACE and RFA or MWA against hepatocellular\ncarcinoma needs more clinical data for a better strategy. The characters and advantages of TACE, RFA, MWA, and TACE\ncombined with RFA or MWA are reviewed to provide physician a better background on decision.
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